Bhandari Lab

The Bhandari Lab is a developmental biology lab focused on BPD and HALI.

team

About Our Lab

The Bhandari Lab is a developmental biology lab focused on understanding the pathogenesis of hyperoxia-induced injury and repair in the developing lungs. Using murine models of bronchopulmonary dysplasia (BPD) and hyperoxic acute lung injury (HALI), we primarily study how molecular mediators and signaling pathways of inflammation, vascularization, and cell death contribute to disease phenotypes. The ultimate aim of the lab is to be able to translate our work into a better understanding of the pathogenesis of BPD in the premature infant to allow improved targeting of therapeutic interventions.

Members of the lab are also working on clinical and translational projects related to the genetic susceptibility to BPD, improvements in non-invasive ventilation of neonates, and screening for biomarkers for neonatal sepsis.

Research Projects

  • Novel drugs for the treatment of BPD
  • Sex differences in BPD
  • BPD-associated pulmonary hypertension
  • Novel biomarkers in BPD
  • Small RNAs as regulatory molecules in BPD
  • Regulatory pathways in BPD
  • Neurodevelopmental changes in BPD
  • Post-translational modifications in BPD
  • Cellular organell dysfunction in BPD
  • Senescence in BPD

Read more about our research projects here.

 

Expression of Chloride Ion Channel (CLIC)4 in Human Baby Lungs

CLIC

bdp-2

bdp-2

Echocardiograph showing parasternal Short Axis View (SAX) in a neonatal mouse heart after exposure to hyperoxia

sax

immuno

MicroCT of lung vasculature showing recovery after treatment with miR34a inhibitors

ct1