Principal Investigator
Vineet Bhandari, MD, DM, FAAP
About Me
My research in the laboratory is on pulmonary developmental pathology, with a primary focus on hyperoxia-induced injury and resolution/repair in developing lungs. Using a variety of ante- and/or post-natal animal models of experimental bronchopulmonary dysplasia (BPD) and hyperoxia-induced acute lung injury (HALI), we study the mechanisms of molecular mediators and signaling pathways of inflammation, alveolarization and vascularization contribution to the disease phenotypes of HALI and BPD. The ultimate aim of the research laboratory is to be able to translate our work into a better understanding of the pathogenesis of HALI and BPD to allow improved targeting of therapeutic interventions. We have long-standing collaborations with physicians and scientists from various Universities and Pharmaceutical companies. Our long-term goal is to identify drug candidates for HALI and BPD. My other research interests include Neonatal Sepsis, BPD-associated Pulmonary Hypertension and use of “OMICS” (genomics, transcriptomics, proteomics, metabolomics and microbiomics) approaches relevant to premature neonates.
I am proud to have been named to SJ Magazine's list of "Top Doctors for Children 2021" in Neonatology.
Publications
Das P, Curstedt T, Agarwal B, Prahaladan VM, Ramirez J, Bhandari S, Syed MA, Salomone F, Casiraghi C, Pelizzi N, Bhandari V. Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits. Front Physiol. 2020 Apr 9;11:266. doi: 10.3389/fphys.2020.00266. eCollection 2020.
Gilfillan M, Das P, Shah D, Alam MA, Bhandari V. Inhibition of microRNA-451 is associated with increased expression of Macrophage Migration Inhibitory Factor and mitigation of the cardio-pulmonary phenotype in a murine model of Bronchopulmonary Dysplasia. Respir Res. 2020 Apr 22;21(1):92. doi: 10.1186/s12931-020-01353-9.
Alam MA, Betal SGN, Aghai ZH, Bhandari V. Hyperoxia causes miR199a-5p-mediated injury in the developing lung. Pediatr Res. 2019 Nov;86(5):579-588. doi: 10.1038/s41390-019-0524-3. Epub 2019 Aug 8.
For a complete list, please see:
https://www.ncbi.nlm.nih.gov/pubmed/?term=bhandari%2C+vineet
Scientists
About Me
Senior Scientist
Assistant Professor, Cooper Medical School of Rowan University (CMSRU)
E&R Building, Room 206
das-pragnya@cooperhealth.edu
My research interests include studying transcriptional regulation during fetal lung development, role of long and short noncoding RNAs, ion channels and post transcriptional regulation of genes during lung development. We have recently identified a novel small molecule immunomodulator that can be targeted towards preventing BPD in neonatal mouse models. We have also shown that small molecular inhibitors can be used as therapeutic targets in association with surfactant, in a lung injury model of preterm rabbits.
Publications
Das P, Curstedt T, Agarwal B, Prahaladan VM, Ramirez J, Bhandari S, Syed MA, Salomone F, Casiraghi C, Pelizzi N, Bhandari V. Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits. Front Physiol. 2020 Apr 9;11:266. doi: 10.3389/fphys.2020.00266. eCollection 2020.
PMID: 32327998
Das P, Panda SK, Agarwal B, Behera S, Ali SM, Pulse ME, Solomkin JS, Opal SM, Bhandari V, Acharya S. Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Sci Rep. 2019 Feb 27;9(1):2904. doi: 10.1038/s41598-019-38731-3.
PMID: 30814582
Leary S*, Das P*, Ponnalagu D, Singh H, Bhandari V.Genetic Strain and Sex Differences in a Hyperoxia-Induced Mouse Model of Varying Severity of Bronchopulmonary Dysplasia. Am J Pathol. 2019 May;189(5):999-1014. doi: 10.1016/j.ajpath.2019.01.014. Epub 2019 Feb 19.
PMID: 30794808
Das P, Syed MA, Shah D, Bhandari V.miR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia. Cell Stress. 2018 Jan 9;2(2):34-36. doi: 10.15698/cst2018.02.1224.
PMID: 31225464
For a complete list, please see:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Pragnya+Das
About Me
Varsha M Prahaladan
Research Assistant
E&R Building, Room 206
prahaladan-varsha@cooperhealth.edu
I am studying the expression of small RNAs in the lungs of mouse models of Experimental BPD and the role of chloride ion channels in the pathogenesis of BPD.
Publications
Das P, Acharya S, Prahaladan VM, Kumova, OK, Malaeb S, Behera S, Agarwal B, Christensen DJ, Carey AJ and Bhandari V. Chitin-Derived AVR-48 Prevents Experimental Bronchopulmonary Dysplasia (BPD) and BPD-Associated Pulmonary Hypertension in Newborn Mice. Int. J. Mol. Sci. 2021, 22, 8547. https://doi.org/10.3390/ijms2216854
Das P, Curstedt T, Agarwal B, Prahaladan VM, Ramirez J, Bhandari S, Syed MA, Salomone F, Casiraghi C, Pelizzi N, Bhandari V. Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits. Front Physiol. 2020 Apr 9;11:266. doi: 10.3389/fphys.2020.00266. eCollection 2020. PMID: 32327998
Das P, Acharya S, Shah D, Agarwal B, Prahaladan VM, Bhandari V. Chitin Analog AVR-25 Prevents Experimental Bronchopulmonary Dysplasia. J Pediatr Intensive Care. 2020 Sep;9(3):225-232. doi: 10.1055/s-0040-1709994. Epub 2020 May 8. PMID: 32685255
Chaubey S, Nader YM, Shah D, Kumova OK, Prahaladan VM, Carey AJ, Andersson S, Bhandari V. α1,3-Fucosyltransferase-IX, an enzyme of pulmonary endogenous lung stem cell marker SSEA-1, alleviates experimental bronchopulmonary dysplasia Pediatr Res. 2021 Apr;89(5):1126-1135. doi: 10.1038/s41390-020-0891-9. Epub 2020 Apr 17. PMID: 32303051